الملخص الإنجليزي
Summary :
Background Studies from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2021 can guide screening and prevention strategies for tracheal, bronchus, and lung (TBL) cancer. We aim to provide global, regional, and national estimates of the TBL cancer burden and its attributable risk from 1990 to 2021, including during the coronavirus disease 2019 (COVID-19) pandemic.
Methods Incidence, age-standardised incidence rate (ASIR), deaths, age-standardised mortality rate (ASMR), disability-adjusted life years (DALYs), age-standardised rate of DALYs (ASDR), and the burden due to risk factors associated with TBL cancer were analysed from 1990 to 2021. Trends in ASIR, ASMR, and ASDR of TBL cancer
during the COVID-19 pandemic (2019–2021) were also determined. All statistical analyses were performed using
Join-point software (version 4.9.1.0).
Findings Between 1990 and 2021, the global incidence, deaths, and DALYs of TBL cancer to varying degrees.
However, the ASIR (Average Annual Percent Change [AAPC], −0.3 [−0.4 to −0.2]), ASMR (AAPC, −0.5 [−0.7
to −0.4]), and ASDR (AAPC, −0.9 [−1.0 to −0.7]) all showed a decreasing trend. However, the ASIR, ASMR, and
ASDR of TBL cancer in males all showed a decreasing trend from 1990 to 2021. In contrast, the ASIR and
ASMR of TBL cancer in females showed an increasing trend, while the ASDR showed a relatively stable trend.
During the COVID-19 pandemic, the trends for ASIR, ASMR, and ASDR remained stable across both sexes
combined, females, males, five socio-demographic index (SDI) quintiles, and the 21 GBD regions. In 2021,
smoking was a major risk factor for TBL cancer DALYs, but the attributable ASDR for smoking decreased from
1990 to 2021 in both sexes combined, as well as individually for males and females. Conversely, the attributable
ASDR for secondhand smoke, high fasting plasma glucose and occupational exposure factors increased
primarily among females. Furthermore, the attributable ASDR for ambient particulate matter pollution,
household air pollution from solid fuels, and low–fruit diets increased primarily in regions with lower SDI
quintiles from 1990 to 2021.
Interpretation The burden attributable to TBL cancer has increased in some populations from 1990 to 2021, highlighting the importance of implementing targeted measures to mitigate this trend. No significant change in the
burden of TBL cancer was observed during the COVID-19 pandemic; however, post-COVID-19 rates still require
further observation.
Funding This study was supported by National Key Research and Development Program of China (2023YFC3503300,
2023YFC3503305), and High Level Chinese Medical Hospital Promotion Project (HLCMHPP2023085,
HLCMHPP2023001, HLCMHPP2023097).
