Abstract : This paper present a new developed technique for robotic surgical model with high flexibility used in Total Knee Replacement (TKR) surgery. The proposed model used robot arm assisted technique to play the role of computer assisted surgery (CAS). Most famous type’s orthopedic surgery equipments used navigation system. The system provide surgeon with extra support, as it help optimizing the implant’s alignment according to structure of the body. The problem faces this types that the device has to be in fixed position during surgery, which limit the ability of the surgeon. Artificial Immunity System (AIS) technology is utilized to obtain two tasks. Processing Computer Tomography (CT) scan of the patient in order to be used by AIS considers the first task. In the second task AIS perform as controller to improve and adjust the movement of the robotic arm. The proposed technique is applied and tested for different cases. The proposed technique shows good results in performing TRK surgery. Keywords: Total knee replacement surgery (TKR); Computer-Assisted Surgery (CAS); Artificial immunity System (AIS); Navigation system; Artificial Immunity System Pattern Recognition (AISPR).