Abstract: Aim. Te study’s aim was to examine the relationship between transformational leadership, organizational justice, and nurses’ quality of work life. Background. Tere is an increasing emphasis on the welfare of nurses and their infuence on healthcare services. Tere is a dearth of comprehensive studies on the infuence of transformational leadership and justice within organizations on work-related quality of life. Understanding these connections is critical for improving workplace dynamics and fostering nurse well-being. Methods.Tis cross-sectional research included a convenience sample of nurses working in a general hospital.Te data were obtained through self-report questionnaires encompassing three reliable and validated scales: the global transformational leadership scale, organizational justice scale, and quality of nursing work-life scale. Te data were then analyzed with SPSS 23 and statistical methods (descriptive statistics, Pearson correlation coefcient, and hierarchical linear regression). Tis study adhered to the STROBE guidelines. Results. A sum of 527 out of 566 nurses responded to the questionnaires (response rate � 93.1%). Te nurses had a high perception of transformational leadership behaviors but had a more moderate view of organizational fairness and the quality of their nursing work life. Transformational leadership was signifcantly associated with organizational fairness. Also, a positive relationship was found between transformational leadership, justice within organizations, and nurses’ quality of work life. Conclusions. Nurses who consider their leaders as transformative and have the sense of a fair organizational climate are more likely to have higher levels of quality of work life. Implications for Nursing Management. Nurse managers should strive to develop transformational leadership behaviors and promote organizational justice to enhance the well-being and satisfaction of nurses in their work environments.