English Abstract
Abstract:
Botanicals are natural alternatives to pharmacological therapies that aim at reducing
hypercholesterolemia. In this context, despite bergamot being effective in modulating lipid profile,
some subjects failed to achieve a satisfactory response to supplementation. The aim of this study
was to evaluate whether the association of 600 mg of bergamot phytosome® (from Citrus Bergamia
Risso) and 100 mg of artichoke leaf standardized dry extract (from Cynara cardunculus L.) can be an
alternative in patients with mild hypercholesterolemia who are poor responders to bergamot in a
2-month randomized placebo-controlled trial. Sixty overweight adults were randomized into two
groups: 30 were supplemented and 30 received a placebo. The metabolic parameters and DXA body
composition were evaluated at the start, after 30 and 60 days. Between the two groups, total and LDL
cholesterol in the supplemented group (compared to placebo) showed significant decreases overtime.
A significant reduction of waist circumference and visceral adipose tissue (VAT) was recorded in
the supplemented group (compared to placebo), even in subjects who did not follow a low-calorie
diet. In conclusion, the synergism between Citrus Bergamia polyphenols and Cynara cardunculus
extracts may be an effective option and may potentially broaden the therapeutic role of botanicals in
dyslipidemic patients.
