Abstract: The importance of heavy oil in the world oil market has increased over the past twenty years as light oil reserves have declined steadily. The high viscosity of this kind of unconventional oil results in high energy consumption for its transportation, which significantly increases production costs. A cost-effective solution for the long-distance transport of viscous crudes could be waterlubricated flow technology. A water ring separates the viscous oil-core from the pipe wall in such a pipeline. The main challenge in using this kind of lubricated system is the need for a model that can provide reliable predictions of friction losses. An artificial neural network (ANN) was used in this study to model pressure losses based on 225 data sets from independent sources. The seven input variables used in the current ANN model are pipe diameter, average velocity, oil density, oil viscosity, water density, water viscosity, and water content. The ANN developed using the backpropagation technique with seven processing neurons or nodes in the hidden layer demonstrated to be the optimal architecture. A comparison of ANN with other artificial intelligence and parametric techniques shows the promising precision of the current model. After the model was validated, a sensitivity analysis determined the relative order of significance of the input parameters. Some of the input parameters had linear effects, while other parameters had polynomial effects of varying degrees on the friction losses.