وثيقة
المعرف
https://digitalrepository.uob.edu.bh/id/bc91df8e-b9d2-4fc9-956a-f40811335a6e
Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects A 2-Month Randomized Double-Blind Placebo-Controlled Trial
وكيل مرتبط
Gasparri, Clara , مختصر
Barrile, Gaetan Claude, مختصر
Battaglia, Santina, مختصر
Cavioni, Alessandro, مختصر
Giusti, Riccardo, مختصر
Moroni, Alessia, مختصر
Nannipieri, Fabrizio, مختصر
Patelli, Zaira, مختصر
دولة النشر
Bahrain
مكان النشر
Sakhir, Bahrain
الناشر
University of Bahrain
تاريخ النشر
2022
اللغة
إنجليزي
الموضوع
الملخص الإنجليزي
Abstract:
Sarcopenia is a complex process characterized by a progressive decrease in muscle mass and strength. Various nutrients have been shown to be effective in supporting muscular performance. This randomized clinical trial aimed to evaluate the effectiveness of a 2-month administration of food for special medical purposes composed of omega-3 fatty acids (500 mg), leucine (2.5 g), and probiotic Lactobacillus paracasei PS23 (LPPS23), on appendicular lean mass (ALM), muscle performance, inflammatory status, and amino acid profile in sarcopenic patients. A total of 60 participants (aged 79.7 ± 4.8 years and a body mass index of 22.2 ± 2.1 kg/m2) were enrolled and randomly assigned to either intervention (n = 22) or placebo group (n = 28). Comparing the differences in effects between groups (intervention minus placebo effects), ALM increased significantly in the intervention group (p < 0.05), with no discernible change in the placebo group. Similarly, significant differences were also observed for the Tinetti scale (+2.39 points, p < 0.05), the SPPB total score (+2.22 points, p < 0.05), and the handgrip strength (4.09 kg, p < 0.05). Visceral adipose tissue significantly decreased in the intervention group compared to the placebo group at 60 days −0.69 g (95% CI: −1.09, 0.29) vs. 0.27 g (95% CI: −0.11, 0.65), groups difference −0.96 (95% CI: −1.52, 0.39, p = 0.001). A statistically significant increase in levels of valine, leucine, isoleucine, and total amino acid profiles was observed in the intervention group compared with the placebo group at 60 days (p = 0.001). When taken together, these beneficial effects may be attributed to the innovative composition of this special medical-purpose food which could be considered for the treatment of sarcopenia in the elderly.
عنوان الدورية
Nutrients
المجموعة
العدد
Volume 14 - Issue 21
قالب العنصر
مقال دورية