Document

Association between des-acyl ghrelin at fasting and predictive index of muscle derangement, metabolic markers and eating disorders: a crosssectional study in overweight and obese adults

Author
Linked Agent
Gasparri , C, Author
Peroni , G, Author
Infantino , V, Author
Iannello , G, Author
Riva , A, Author
Alalwan , T.A, Author
Title of Periodical
Nutritional Neuroscience
Country of Publication
Kingdom of Bahrain
Place Published
sakhir, bahrain
Publisher
University of Bahrain
Date Issued
2022
Language
English
English Abstract
ABSTRACT: Background: This study aimed to analyse the impact of des-acyl and acyl ghrelin (AG) on a wide range of muscular and metabolic markers and in order to discover the possible relationships and interactions of des-acylated ghrelin (DAG) on eating disorders. Materials & Methods: A total of 88 subjects (64 women and 24 men, with a mean age of 43 years and a mean body mass index (BMI) of 30.20 ± 3.27 kg/m2) were enrolled in the cross-sectional study. Results: The findings showed that for each unit of increase of free fat mass index (FFMI), levels of DAG decreased by −41.11 pg/mL (p < 0.05). Moreover, similar associations with DAG were found for insulin (β = −30.67; p < 0.001), leptin (β = −0.64; p < 0.05), body weight (β = −14.36; p < 0.001), and free fat mass (FFM) (β = −30.67; p < 0.001). In addition, associations were found between DAG and resting energy expenditure (REE) (β = −0.84; p = 0.05) and the binge eating scale (BES) in which a unit increase of the BES score Q3 (depression) correlated with a decrease of DAG levels (β = −9.98; p = 0.08). Further, a unit increase of AG/DAG ratio correspond with an increase in body weight (β = 12.20; p < 0.05), BMI (β = 4.70; p < 0.05) and fat mass (β = 7.30; p < 0.05). However, the AG/DAG ratio was not associated with FFMI (β = 2.61; p = 0.165) and FFML/BMI (β = −0,064; p = 0.625). Conclusion: This study suggests that higher levels of DAG at fasting are indices of poor muscle mass, insulin resistance and depression.
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Identifier
https://digitalrepository.uob.edu.bh/id/5eae4331-831e-4ecd-ac23-2b90a36c1dc3