Abstract: Today, the global community is appreciating green technologies in the application of green products in textiles. The aim of the current study is to use a sustainable heating technique for the isolation of colorant from plant sources and to use eco-friendly anchors to improve the fastness of dyed fabrics with new shades. The current study used microwave radiation to isolate natural colorants from saffron (Crocus sativus) and safflower (Carthamus tinctorius L.) petals for polyamide (nylon) fabric dyeing. For this purpose, acidic extract and fabric were exposed to MW treatment for up to 6 min and employed at various conditions. To make the dyeing process sustainable, bio-mordants have been employed and compared with synthetic mordants. It has been found that 6 min is the optimal radiation time for the isolation of colorant to get good results onto irradiated polyamide (nylon) fabric when employed at 65 ◦C for 45 min containing 1 g/100 mL of table salt for saffron and 3 g/100 mL of table salt for safflower dyeing. For improving color strength and giving an acceptable rating of fastness, 7% of turmeric as a pre-bio mordant and 7% pomegranate as a post-mordant has given high results using saffron extract. Similarly, with safflower extract, 5% of turmeric as a pre-mordant and 5% of turmeric extracts as a post-mordant have given high results as compared to chemical mordants used. It is concluded that microwave treatment has a high potential for investigating the coloring efficacy of crocin-containing saffron petals and safflower petals as carthamin as a yellow natural dye for bio-mordanted polyamide fabrics. It is recommended that such tools for the isolation of colorant from new dye-producing plants should be used, whereas green mordants should be used to develop new colorfast shades to make process more green and sustainable